Van de Ven Double Ends The Toffees' Run at Brand New Stadium
Micky van de Ven emerged as the initial defender to score two goals in a English top-flight game for Spurs since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven nods home twice in opening period
The home side's defender has goal ruled after VAR review
Pape Matar Sarr scores final goal in dying moments
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven found the net twice as Tottenham extended their winning streak on the road in the Premier League and handed Everton their first defeat at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after more than a century at the conclusion of last season.
But Spurs captain Van de Ven struck on two occasions from set-pieces in the first half to place their strong form at risk, and they were failed to turn it around before the midfielder - set up by ex-Everton forward Richarlison - headed home a final goal to put the game to bed.
Jake O'Brien believed he had levelled the tally five minutes after Van de Ven's first goal, glancing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of chances, while the Italian goalkeeper made a series of fine stops to guarantee the London club went five away games without defeat in the Premier League.
But the video assistant referee intervened, advising Craig Pawson to review the score on the pitchside monitor and the official decided that the winger and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win elevates the manager's team into third place in the Premier League, five points off north London rivals and leaders the Gunners.
The Merseyside club remain in 14th position and are six points clear of the relegation zone.
Tottenham analysis: Van de Ven excels in role at both ends of the field
Following a uninspiring midweek performance in the European competition against Monaco, where they managed a only attempts on goal, the manager opted for the French striker up front instead of ex-Everton forward Richarlison.
The new arrival was failed to make much of an impact before being replaced for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the final outcome.
Centre-back the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's first goal came from a well-worked corner routine, with Rodrigo Bentancur heading the ball toward the face of goal for an unmarked Van de Ven to head home.
And Ven de Ven - filling in as skipper in the Argentine's unavailability - added his next goal in added time as he rose above the England keeper to nod in.
The Dutchman was just as impressive in defensive duties, combining well with Kevin Danso as the duo dealt excellently with the numerous deliveries sent their way by the opposition.
Everton analysis: Everton lacking finishing touch
Everton's new home had been a happy hunting ground, but it appears the novelty may have worn off somewhat and fans flocked to the exits after Sarr's third for Spurs.
The break in Everton's winning streak at home will not be a massive worry for the manager, but their striker situation will be.
The forward and Thierno Barry - the Everton's two recognised strikers - had scored only a single goal combined before the weekend's match.
And they were failed to add to that miserable record on a wet and gloomy night on Merseyside.
The striker's performance was epitomized when he chose to bicycle-kick a clear chance from near the goal, even with having space and time to readjust for a simpler shot that would have challenged Vicario.
Barry, too, was unable to make an impact after coming on for Beto in the 65th minute.
It was not for a shortage of opportunity. The majority of the home side's offensive moves came through the winger and Ndiaye, who relentlessly delivered dangerous crosses into the Tottenham box.
What next for these two sides?
The Toffees: Moyes' men head to Sunderland in the top flight on early November at 20:00 GMT.
Tottenham: Spurs travel to St James' Park on late October for their fourth-round Carabao Cup match against Newcastle.